At 18:55 CST, a Cessna 414 crashed about 2 minutes after departure from the Monroe Regional Airport. The airplane was substantially damaged and the pilot and single passenger were seriously injured. Air Traffic Control data revealed that the airplane was cleared for takeoff from runway 04 at 18:53. The controller heard a noise and the ELT signal at 18:54:50. Two witnesses heard a rattling sound and saw a fire. The weather at the time was visibility of 1/4 statute mile in fog with a vertical visibility of 100 feet and calm winds.