At about 1235 Eastern time, the airplane was destroyed when it impacted a residence shortly after takeoff. The Commercial pilot was seriously injured and three passengers were fatally injured. Visual conditions prevailed; an IFR flight plan had been filed for the cross-country flight. One witness reported that the airplane used the majority of the 5001-foot runway and didnt appear to gain altitude. A second witness stated that the accident airplanes engine sounded like it was missing for a period of approximately 10 seconds. The airplane descended in an upright attitude, impacting the residence. According to another witness, the pilot repeated that he couldnt get air, couldnt get altitude after the crash.